13-03009. Diamthazole Dihydrochloride [Archived]

Nomenclature

CAS number: 136-96-9
6-[2-(Diethylamino)ethoxy]-N,N-dimethyl-2-benzothiazolamine dihydrochloride; 6-[2-(diethylamino)ethoxy]-2-dimethylaminobenzothiazole dihydrochloride; 2-dimethylamino-6-(β-diethylaminoethoxy)benzothiazole dihydrochloride; dimazole dihydrochloride; Ro-2-2453; Asterol Dihydrochloride (Roche); Atelor (Roche).
C15H25Cl2N3OS; mol wt 366.35.
C 49.18%, H 6.88%, Cl 19.35%, N 11.47%, O 4.37%, S 8.75%.

Description and references

Prepn: Steiger, Keller, US 2578757 (1951 to Hoffmann-La Roche).

Chemical structure

Properties

Crystals, dec 269°, mp 240-243°. Freely sol in water, methanol, ethanol. A 5% aq soln has a pH of ≈2.

Therapeutic Category

Antifungal.

Keywords

Antifungal (Synthetic)

Status

This monograph has been retired and is no longer subject to revision or update.