13-03097. Dichlorophenarsine Hydrochloride [Archived]

Nomenclature

CAS number: 536-29-8
(3-Amino-4-hydroxyphenyl)arsonous dichloride monohydrochloride; (3-amino-4-hydroxyphenyl)dichloroarsine hydrochloride; RP-2591; Arseclor; Chlorarsen; Chlorarsol; Clorarsen; Dichloro-Mapharsen; Filarsen; Fontarsol; Halarsol.
C6H7AsCl3NO; mol wt 290.41.
C 24.81%, H 2.43%, As 25.80%, Cl 36.62%, N 4.82%, O 5.51%.

Description and references

Prepd by the action of arsenic trichloride on o-aminophenol, or from the corresp arsine oxide and an excess of HCl: DE 281101; from arsphenamine by treatment with mercuric chloride and HCl gas: Binz, Bauer, Z. Angew. Chem. 34, 261 (1921). Toxicity: Beck, Proc. Soc. Exp. Biol. Med. 78, 392 (1951).

Chemical structure

Properties

White hygroscopic powder. mp 200°. Readily sol in water yielding a soln of oxophenarsine. Usually marketed mixed with 3.33 times its weight of sodium citrate-carbonate as buffer to make a soln of pH 6.2 isotonic with human blood. LD50 i.p. in mice: 41 mg/kg (Beck).

Therapeutic Category

Formerly as antisyphilitic.

Therapeutic Category (Veterinary)

Has been used as a filaricide.

Keywords

Antisyphilitic

Status

This monograph has been retired and is no longer subject to revision or update.