13-03133. Diethadione [Archived]

Nomenclature

CAS number: 702-54-5
5,5-Diethyldihydro-2H-1,3-oxazine-2,4(3H)-dione; 5,5-diethyl-2,3,5,6-tetrahydro-4H-1,3-oxazine-2,4-dione; Dioxone; Ledosten; Persisten; Tocèn (Lepetit).
C8H13NO3; mol wt 171.19.
C 56.13%, H 7.65%, N 8.18%, O 28.04%.

Description and references

Prepn: Testa et al., J. Org. Chem. 24, 1928 (1959); GB 855244 (1960 to Lepetit, SpA). Toxicity study: Maffii et al., J. Pharm. Pharmacol. 13, 244 (1961).

Chemical structure

Properties

Crystals from ether, mp 97-98°. LD50 in mice, rats (mg/kg): 52, 31.6 i.p.; 130, 70.5 orally (Maffii).

Therapeutic Category

Analeptic.

Keywords

Anticonvulsant

Status

This monograph has been retired and is no longer subject to revision or update.