13-03398. Disulfamide [Archived]

Nomenclature

CAS number: 671-88-5
4-Chloro-6-methyl-1,3-benzenedisulfonamide; 5-chlorotoluene-2,4-disulfonamide; 2-chloro-4-methylbenzene-1,5-disulfonamide; 5-chloro-2,4-disulfamyltoluene; disulphamide; Disamide (BDH); Natirene 25.
C7H9ClN2O4S2; mol wt 284.74.
C 29.53%, H 3.19%, Cl 12.45%, N 9.84%, O 22.48%, S 22.52%.

Description and references

Prepn: GB 851287 (1960 to Brit. Drug Houses). Pharmacology: David, Fellowes, J. Pharm. Pharmacol. 12, 65 (1960).

Chemical structure

Properties

Non-hygroscopic cryst powder, mp 260°. uv max (ethanol): 285 nm (ε 805). Practically insol in water. Slightly sol in ethanol. Soly in abs ethanol at 25° = 1.89% w/w; in 90% ethanol = 2.23% w/w; in isopropanol = 0.35%; in chloroform = 0.001%. Sol in cold NaOH solns.

Therapeutic Category

Diuretic.

Keywords

Diuretic; Sulfonamide Derivatives

Status

This monograph has been retired and is no longer subject to revision or update.