13-03925. Etymemazine [Archived]

Nomenclature

CAS number: 523-54-6
2-Ethyl-N,N,β-trimethyl-10H-phenothiazine-10-propanamine; 10-[3-(dimethylamino)-2-methylpropyl]-2-ethylphenothiazine; 3-ethyl-10-(3-dimethylamino-2-methylpropyl)phenothiazine; 3-(3-ethyl-10-phenothiazinyl)-2-methyl-1-dimethylaminopropane; ethotrimeprazine; ethylisobutrazine; RP-6484; Diquel.
C20H26N2S; mol wt 326.50.
C 73.57%, H 8.03%, N 8.58%, S 9.82%.

Description and references

Prepn: Jacob, Robert, US 2837518 (1958 to Rhne-Poulenc). Activity studies in pigs: Lambrerth, Aust. Vet. J. 44, 333 (1968). Biotransformation studies: Robinson, J. Pharm. Pharmacol. 18, 19 (1966).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 3737-33-5
Nuital (Vaillant-Defresne); Sergetyl (Vaillant-Defresne).
C20H26N2S.HCl; mol wt 362.96.
C 66.18%, H 7.50%, N 7.72%, S 8.83%, Cl 9.77%.

Properties

mp 160-163°. Soluble in water, ethanol, methanol, acetone, chloroform. Practically insol in ether.

Therapeutic Category

Antihistaminic.

Therapeutic Category (Veterinary)

Tranquilizer.

Keywords

Antihistaminic; Tricyclics; Phenothiazines

Status

This monograph has been retired and is no longer subject to revision or update.