13-04569. Guaiapate [Archived]

Nomenclature

CAS number: 852-42-6
1-[2-[2-[2-(2-Methoxyphenoxy)ethoxy]ethoxy]ethyl]piperidine; MG-5454; Klamar (Maggioni).
C18H29NO4; mol wt 323.43.
C 66.84%, H 9.04%, N 4.33%, O 19.79%.

Description and references

Basic ether deriv of guaiacol, q.v. Prepn: M. Carissimi, F. Ravenna, FR 1386633; eidem, US 3320254 (1965, 1967 both to Maggioni); M. Carissimi et al., J. Med. Chem. 8, 542 (1965). Pharmacological and clinical studies: G. Barbi, Gazz. Med. Ital. 127, 13 (1968). Analytical study: S. Cavicchi et al., Boll. Chim. Farm. 108, 682 (1969).

Chemical structure

Properties

Liq, bp0.5 190-193°. LD50 i.p. in mice: 254 μmoles/kg (Carissimi).

Therapeutic Category

Antitussive.

Keywords

Antitussive

Status

This monograph has been retired and is no longer subject to revision or update.