13-05122. Isbogrel [Archived]

Nomenclature

CAS number: 89667-40-3
(E)-7-Phenyl-7-(3-pyridinyl)-6-heptenoic acid; CV-4151.
C18H19NO2; mol wt 281.35.
C 76.84%, H 6.81%, N 4.98%, O 11.37%.

Description and references

Thromboxane A2 (TXA2) synthetase inhibitor. Prepn: S. Terao, K. Nishikawa, EP 98690; eidem, US 4518602 (1984, 1985 both to Takeda); and inhibition of TXA2: K. Kato et al., J. Med. Chem. 28, 287 (1985). Pharmacology: Z. Terashita et al., Thromb. Res. 41, 223 (1986). Antithrombotic effect in experimental thrombi: T. Matsubara et al., Am. Heart J. 118, 837 (1989). Clinical pharmacokinetics: T. Kuzuya et al., Cardiovasc. Drugs Ther. 2, 693 (1988). Clinical trial: R. Hattori et al., Jpn. Circ. J. 55, 324 (1991).

Chemical structure

Properties

mp 114-115°.

Therapeutic Category

Antithrombotic.

Keywords

Antithrombotic; Thromboxane A2-Sythetase Inhibitor

Status

This monograph has been retired and is no longer subject to revision or update.