13-05872. Mepazine [Archived]

Nomenclature

CAS number: 60-89-9
10-[(1-Methyl-3-piperidinyl)methyl]-10H-phenothiazine; (N-methyl-3-piperidyl)methylphenothiazine; mepasin; pecazine; MPMP; P-391; III-2318; Paxital (Warner-Chilcott); Lacumin; Pacatal (Warner-Chilcott); Nothiazine; Pacatol.
C19H22N2S; mol wt 310.46.
C 73.50%, H 7.14%, N 9.02%, S 10.33%.

Description and references

Prepn: Schuler, US 2784185 (1952 to Promonta).

Chemical structure

Properties

bp4 230-235°.

Derivative

Hydrochloride monohydrate.
C19H23ClN2S.H2O; mol wt 364.93.
C 62.53%, H 6.91%, Cl 9.72%, N 7.68%, S 8.79%, O 4.38%.

Properties

Crystals, mp 180-181°. Photosensitive. Protect from light. Slightly bitter taste. Very slightly sol in water; freely sol in abs ethanol; sol in chloroform. Practically insol in ether, benzene.

Therapeutic Category

Antipsychotic.

Therapeutic Category (Veterinary)

Tranquilizer.

Keywords

Antipsychotic; Phenothiazines

Status

This monograph has been retired and is no longer subject to revision or update.