12-05902. Mepiprazole [Archived]

Nomenclature

CAS number: 20326-12-9
1-(3-Chlorophenyl)-4-[2-(5-methyl-1H-pyrazol-3-yl)ethyl]piperazine; 3-[2-(N′-m-chlorophenylpiperazino)ethyl]-5-methylpyrazole; EMD-16923.
C16H21ClN4; mol wt 304.82.
C 63.04%, H 6.94%, Cl 11.63%, N 18.38%.

Description and references

Psychotropic agent with CNS-depressant effects. Prepn: V. Koppe et al., GB 1124710; eidem, US 3491097 (1968, 1970 both to E. Merck); eidem, Eur. J. Med. Chem. 10, 154, 162 (1975). Pharmacological study: M. A. Ruch-Monachon et al., Arch. Int. Pharmacodyn. Ther. 219, 326 (1976). Effects on brain biogenic amine metabolism: C. Seyfried et al., Arzneim.-Forsch. 26, 1088 (1976). EEG effects in rabbits: S. Watanabe et al., ibid. 29, 274 (1979).

Chemical structure

Properties

Crystals, mp 106°.

Derivative

Dihydrochloride.

Nomenclature

CAS number: 20344-15-4
H-4007; Psigodal (Merck KGaA).
C16H21ClN4.2HCl; mol wt 377.74.
C 50.87%, H 6.14%, Cl 28.16%, N 14.83%.

Properties

Cryst from ethanol, mp 234°.

Therapeutic Category

Tranquilizer.

Status

This monograph has been retired and is no longer subject to revision or update.