13-05972. Methafurylene [Archived]

Nomenclature

CAS number: 531-06-6
N-(2-Furanylmethyl)-N′,N′-dimethyl-N-2-pyridinyl-1,2-ethanediamine; 2-[(2-dimethylaminoethyl)furfurylamino]pyridine; N,N-dimethyl-N′-(2-pyridyl)-N′-furfurylethylenediamine; N′-(2-furylmethyl)-N′-(2-pyridyl)-N,N-dimethylethylenediamine.
C14H19N3O; mol wt 245.32.
C 68.54%, H 7.81%, N 17.13%, O 6.52%.

Description and references

Prepn: Vaughan, Anderson, J. Am. Chem. Soc. 70, 2607 (1948); Kyrides, Zienty, ibid. 71, 1122 (1949); Horclois, US 2502151 (1950 to Rhne-Poulenc).

Chemical structure

Properties

Light yellow oil, bp0.2 117.5-118°.

Derivative

Hydrochloride.
C14H19N3O.HCl; mol wt 281.78.
C 59.67%, H 7.15%, N 14.91%, O 5.68%, Cl 12.58%.

Properties

Needles from ethyl acetate, mp 117-119°.

Derivative

Dihydrogen citrate.
C14H19N3O.C6H8O7; mol wt 437.44.
C 54.91%, H 6.22%, N 9.61%, O 29.26%.

Properties

Crystals from methanol-ether or from methyl ethyl ketone, mp 95-97°.

Derivative

Fumarate.

Nomenclature

CAS number: 5429-41-4
F-151; Foralamin (Eaton).
C14H19N3O.C4H4O4; mol wt 361.39.
C 59.82%, H 6.41%, N 11.63%, O 22.14%.

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Ethylenediamine Derivatives

Status

This monograph has been retired and is no longer subject to revision or update.