13-06286. Mopidamol [Archived]

Nomenclature

CAS number: 13665-88-8
2,2′,2′′,2′′′-[[4-(1-Piperidinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetrakisethanol; 2,2′,2′′,2′′′-[(4-piperidinopyrimido[5,4-d]-pyrimidine-2,6-diyl)dinitrilo]tetraethanol; 2,6-bis(diethanolamino)-4-piperidinopyrimido[5,4-d]pyrimidine; RA-233; Rapenton (Thomae).
C19H31N7O4; mol wt 421.49.
C 54.14%, H 7.41%, N 23.26%, O 15.18%.

Description and references

An inhibitor of platelet aggregation with antimetastatic properties. Prepn: GB 1051218 corresp to J. Roch, H. Scheffler, US 3322755 (1966, 1967 both to Boehringer, Ing.). Effect on tumor cell metastasis: J. L. Ambrus et al., J. Med. 9, 183 (1978); on inhibition of adenosine uptake into platelets: J. P. Lips et al., Biochem. Pharmacol. 29, 43 (1980). Therapeutic use: R. L. Clark, Cancer 43, 790 (1979); I. L. Bonta et al., Agents Actions Suppl. 4, 278 (1979).

Chemical structure

Properties

Deep yellow crystals, mp 157-158°.

Therapeutic Category

Antineoplastic.

Status

This monograph has been retired and is no longer subject to revision or update.