13-06456. Nealbarbital [Archived]

Nomenclature

CAS number: 561-83-1
5-(2,2-Dimethylpropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-allyl-5-neopentylbarbituric acid; nealbarbitone; neallymal; Nevental (Pharmacia); Censedal (M & B).
C12H18N2O3; mol wt 238.28.
C 60.49%, H 7.61%, N 11.76%, O 20.14%.

Description and references

Synthesis: Brandstrom, Acta Chem. Scand. 13, 613, 615, 619 (1959); GB 797017 and US 2899435 (1958, 1959, both to Pharmacia). Metabolism: J. N. T. Gilbert et al., J. Pharm. Pharmacol. 26, 119 (1974); J. N. T. Gilbert, J. W. Powell, Eur. J. Drug Metab. Pharmacokinet. 3, 195 (1978).

Chemical structure

Properties

Slightly bitter crystals, mp 155-157°. Practically insol in water, petr ether. Moderately sol in chloroform; freely sol in alcohol, ether, acetone. Also sol in aq alkaline solns.

Note

This is a controlled substance (depressant): 21 CFR, 1308.13.

Therapeutic Category

Sedative, hypnotic.

Keywords

Sedative/Hypnotic; Barbituric Acid Derivatives

Status

This monograph has been retired and is no longer subject to revision or update.