13-06460. Nebracetam [Archived]

Nomenclature

CAS number: 97205-34-0
4-(Aminomethyl)-1-(phenylmethyl)-2-pyrrolidinone; (±)-4-(aminomethyl)-1-benzyl-2-pyrrolidinone; WEB-1881.
C12H16N2O; mol wt 204.27.
C 70.56%, H 7.89%, N 13.71%, O 7.83%.

Description and references

Cognition enhancer with cholinergic and cytoprotectant activity. Prepn: K. H. Weber et al., DE 3336024; eidem, US 4833140 (1985, 1989, both to Boehringer, Ing.). Pharmacology: F. J. Kuhn et al., Arch. Int. Pharmacodyn. Ther. 292, 13 (1988). Toxicology: T. Yabe et al., Oyo Yakuri 44, 417 (1992), C.A. 117, 245471s (1992). Clinical effect on cognitive processes: T. F. Münte et al., Neuropsychobiology 19, 158 (1988). Clinical evaluation in Alzheimer's disease: K. Urakami et al., Clin. Neuropharmacol. 16, 347 (1993).

Chemical structure

Derivative

Fumarate.

Nomenclature

CAS number: 97205-35-1
WEB-1881FU.
(C12H16N2O)2.C4H4O4; mol wt 524.61.
C 64.10%, H 6.92%, N 10.68%, O 18.30%.

Properties

Crystals, mp 192-194°. LD50 in male, female rats (mg/kg): 257, 257 i.v.; 2884, 3622 orally (Yabe).

Therapeutic Category

Nootropic.

Keywords

Nootropic

Status

This monograph has been retired and is no longer subject to revision or update.