13-07311. Phenglutarimide [Archived]

Nomenclature

CAS number: 1156-05-4
3-[2-(Diethylamino)ethyl]-3-phenyl-2,6-piperidinedione; 2-(2-diethylaminoethyl)-2-phenylglutarimide; α-phenyl-α-(diethylaminoethyl)glutarimide; 3-phenyl-3-(β-diethylaminoethyl)-2,6-dioxopiperidine.
C17H24N2O2; mol wt 288.38.
C 70.80%, H 8.39%, N 9.71%, O 11.10%.

Description and references

Anticholinergic. Prepn: Tagmann et al., Helv. Chim. Acta 35, 1235 (1952); 37, 185 (1954); Hoffmann, Tagmann, US 2664424 (1953 to Ciba).

Chemical structure

Properties

Crystals from isopropanol, mp 125-127°. Can also be crystallized from a mixture of ethyl acetate and ligroin.

Derivative

Hydrochloride.

Nomenclature

CAS number: 1674-96-0
Aturbane (Novartis); Aturbal.
C17H24N2O2.HCl; mol wt 324.85.
C 62.85%, H 7.76%, N 8.62%, O 9.85%, Cl 10.91%.

Properties

Crystals from methanol + ethyl acetate, dec 168-172°, also 176-177°. Freely sol in water. Dec by alkali.

Therapeutic Category

Antiparkinsonian.

Keywords

Antiparkinsonian; Antimuscarinic

Status

This monograph has been retired and is no longer subject to revision or update.