Nomenclature
CAS number: 55-52-7
(1-Methyl-2-phenylethyl)hydrazine; (α-methylphenethyl)hydrazine; (1-benzylethyl)hydrazine; 1-phenyl-2-hydrazinopropane; β-phenylisopropylhydrazine; PIH.
C
9H
14N
2; mol wt 150.22.
C 71.96%, H 9.39%, N 18.65%.
C
6H
5CH
2CH(CH
3)NHNH
2.
Description and references
Prepn of dl-form: Biel et al., J. Am. Chem. Soc. 80, 1519 (1958); 81, 2805 (1959); Biel, US 2978461 and US 3000903 (both to Lakeside). Resolution of stereoisomers:
Bernstein et al., J. Am. Chem.
Soc. 81, 4433 (1959). Synthesis: Biel et al., ibid. 4995.
Derivative
dl-Form.
Nomenclature
CAS number: 52031-11-5
Properties
Liquid, bp0.5 82-86°. nD20 1.5401.Derivative
dl-Form hydrochloride.
Nomenclature
CAS number: 54779-57-6
JB-516; Catral; Catron; Catroniazid; Cavodil.
C
9H
14N
2.HCl; mol wt 186.68.
C 57.90%, H 8.10%, N 15.01%, Cl 18.99%.
Properties
Crystals, mp 124-125°.Derivative
d-Form.
Properties
bp10 135-138°. nD20 1.5385. [α]D25 +4.5° (c = 5 in methanol).Derivative
d-Form hydrochloride.
Properties
Crystals, mp 152-154°. [α]D25 +12.8° (c = 5 in water); also
reported as mp 148-149°, [α]D25 +13.8° (c = 1 in water).Derivative
l-Form.
Properties
bp10 135-138°. nD20 1.5385. [α]D25 4.5° (c = 5 in methanol).Derivative
l-Form hydrochloride.
Properties
Crystals, mp 152-154°. [α]D25 12.5° (c = 5 in water); also
reported as mp 148-149°, [α]D25 14.0° (c = 1.0 in water).Therapeutic Category
Antihypertensive.
Keywords
Antihypertensive; Hydrazines/Phthalazines
Status
This monograph has been retired and is no longer subject
to revision or update.