13-07560. Piperylone [Archived]

Nomenclature

CAS number: 2531-04-6
4-Ethyl-1,2-dihydro-2-(1-methyl-4-piperidinyl)-5-phenyl-3H-pyrazol-3-one; 4-ethyl-1-(1-methyl-4-piperidyl)-3-phenyl-3-pyrazolin-5-one; 1-(N-methylpiperid-4-yl)-3-phenyl-4-ethylpyrazol-5-one; PR-66.
C17H23N3O; mol wt 285.38.
C 71.55%, H 8.12%, N 14.72%, O 5.61%.

Description and references

Prepn: Ebnother et al., Helv. Chim. Acta 42, 1201 (1959); Jucker et al., US 2903460 (1959 to Sandoz).

Chemical structure

Properties

Crystals from methanol + ether, dec 162-163°. pK1 5.90; pK2 9.15. Very sparingly sol in water. Sol in ethanol, isopropanol, acetone, ethyl acetate.
Ingredient of Palerol (Pelerol).

Derivative

Hydrobromide.
C17H23N3O.HBr; mol wt 366.30.
C 55.74%, H 6.60%, N 11.47%, O 4.37%, Br 21.81%.

Properties

Crystals from methanol + ether, dec 194-197°. Sol in water.

Derivative

Tartrate.

Properties

Crystals from methanol, mp 145-147°.

Therapeutic Category

Analgesic.

Keywords

Analgesic (Non-Narcotic)

Status

This monograph has been retired and is no longer subject to revision or update.