13-07571. Pirazolac [Archived]

Nomenclature

CAS number: 71002-09-0
4-(4-Chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-acetic acid; ZK-76604.
C17H12ClFN2O2; mol wt 330.74.
C 61.73%, H 3.66%, Cl 10.72%, F 5.74%, N 8.47%, O 9.67%.

Description and references

Prepn: BE 844972; H. Ahrens et al., US 4042706 (both 1977 to Schering AG); H. Biere et al., Eur. J. Med. Chem. - Chim. Ther. 17, 27 (1982). Pharmacokinetics: U. Tuber et al., Eur. J. Drug Metab. Pharmacokinet. 10, 41 (1985). Effect on arachidonic acid metabolism in human synovia: M. Kurowski et al., Curr. Med. Res. Opin. 10, 494 (1987). Preliminary clinical trial in rheumatoid arthritis: D. Symmons et al., ibid. 9, 542 (1985).

Chemical structure

Properties

Crystals from ethanol + water, mp 148-149°. Also reported as second crystalline modification from toluene, mp 135-136°.

Therapeutic Category

Anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives

Status

This monograph has been retired and is no longer subject to revision or update.