13-07591. Pirprofen [Archived]

Nomenclature

CAS number: 31793-07-4
3-Chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)-α-methylbenzeneacetic acid; 3-chloro-4-(3-pyrrolin-1-yl)hydratropic acid; Su-21524; Rangasil (Novartis); Rengasil (Novartis); Seflenyl (Novartis).
C13H14ClNO2; mol wt 251.71.
C 62.03%, H 5.61%, Cl 14.08%, N 5.56%, O 12.71%.

Description and references

Non-steroidal anti-inflammatory. Prepn: R. W. Carney, G. DeStevens, US 3641040 (1972 to Ciba); R. W. Carney et al., Experientia 29, 938 (1973). Metabolism: R. C. Luders et al., Clin. Pharmacol. Ther. 21, 721 (1977). Pharmacology: G. Wilhelmi, Pharmacology 16, 268 (1978). Pharmacokinetics: M. Beth et al., J. Clin. Pharmacol. 15, 563 (1975). Comparative efficacy: R. J. Saykaly et al., ibid. 19, 59 (1979). Review of pharmacology and therapeutic efficacy: P. A. Todd, R. Beresford, Drugs 32, 509-537 (1986).

Chemical structure

Properties

Crystals from benzene-hexane, mp 98-100°.

Therapeutic Category

Anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal); Arylpropionic Acid Derivatives

Status

This monograph has been retired and is no longer subject to revision or update.