13-08963. Suclofenide [Archived]

Nomenclature

CAS number: 30279-49-3
3-Chloro-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)benzenesulfonamide; 3-chloro-4-(phenylsuccinimido)benzenesulfonamide; 1-(α-phenylsuccinimido)-2-chloro-4-sulfamoylbenzene; 1-(2-chloro-4-sulfamoylphenyl)-3-phenylsuccinimide; CGP-8426; GS-385; Sulfalepsin (Geistlich).
C16H13ClN2O4S; mol wt 364.80.
C 52.68%, H 3.59%, Cl 9.72%, N 7.68%, O 17.54%, S 8.79%.

Description and references

Anti-epileptic agent. Prepn: R. W. Pfirrmann, BE 752109; idem, US 3789056 (1970, 1974 both to Geistlich). Pharmacology: Arzneim.-Forsch. 27, 1942 (1977). HPLC determn in biological materials: F. Mikes et al., ibid. 29, 1583 (1979).

Chemical structure

Properties

Crystals from methanol/ether-petroleum ether, mp 205-207°. LD50 orally in mice: >5000 mg/kg (Mikes).

Therapeutic Category

Anticonvulsant.

Keywords

Anticonvulsant

Status

This monograph has been retired and is no longer subject to revision or update.