13-09038. 4,4′-Sulfinyldianiline [Archived]

Nomenclature

CAS number: 119-59-5
4,4′-Sulfinylbisbenzeneamine; di(p-aminophenyl) sulfoxide; 4,4′-diaminodiphenyl sulfoxide; bis(p-aminophenyl) sulfoxide; Medapsol.
C12H12N2OS; mol wt 232.30.
C 62.04%, H 5.21%, N 12.06%, O 6.89%, S 13.80%.

Description and references

Analog of dapsone. Prepn: Gazdar, Smiles, J. Chem. Soc. 93, 1835 (1908); GB 509415 (1939 to I. G. Farbenind.), C.A. 34, 3764 (1940); Berti et al., Rev. Bras. Leprol. 20, 104 (1952), C.A. 50, 11520 (1956). In vivo activity vs Mycobacterium leprae: L. Levy, Antimicrob. Agents Chemother. 14, 791 (1978).

Chemical structure

Properties

Prisms from alc or water, mp 175°. Slightly sol in water.

Therapeutic Category

Antibacterial (leprostatic).

Status

This monograph has been retired and is no longer subject to revision or update.