13-09073. Sulisatin [Archived]

Nomenclature

CAS number: 54935-03-4
1,3-Dihydro-7-methyl-3,3-bis[4-(sulfooxy)phenyl]-2H-indol-2-one; 3,3-bis(p-hydroxyphenyl)-7-methyl-2-indolinone bis(hydrogen sulfate) (ester).
C21H17NO9S2; mol wt 491.49.
C 51.32%, H 3.49%, N 2.85%, O 29.30%, S 13.05%.

Description and references

Deriv of isatin, which stimulates motility of the large intestine. Prepn: A. Hosta Pujol, S. Brosa Rabassa, DE 2521966 corresp to US 4053483 (1975, 1977 both to Andreu); F. Garrido et al., Eur. J. Med. Chem. 10, 143 (1975). Mechanism of action: J. Queralt et al., Arch. Farmacol. Toxicol. 1, 137 (1975). Laxative properties: M. Moreto et al., Eur. J. Pharmacol. 36, 221 (1976). Metabolism: eidem, Arzneim.-Forsch. 29, 1561 (1979).

Chemical structure

Derivative

Disodium salt.

Nomenclature

CAS number: 54935-04-5
DAN-603; Laxitex (Andreu).
C21H15NNa2O9S2; mol wt 535.45.
C 47.11%, H 2.82%, N 2.62%, Na 8.59%, O 26.89%, S 11.98%.

Properties

White crystals, mp >360°. Slightly hygroscopic.

Therapeutic Category

Laxative.

Keywords

Laxative/Cathartic

Status

This monograph has been retired and is no longer subject to revision or update.