13-09077. Suloctidil [Archived]

Nomenclature

CAS number: 54063-56-8
4-[(1-Methylethyl)thio]-α-[1-(octylamino)ethyl]benzenemethanol; erythro-p-(isopropylthio)-α-[1-(octylamino)ethyl]benzyl alcohol; 1-(4-isopropylthiophenyl)-2-octylaminopropanol; CP-556S; MJF-12637; Bemperil (Sidus); Cerebro (Sidus); Circleton (IBI); Dulasi (Dukron); Duloctil (Searle); Euvasal (Synthelabo); Fluversin (Searle); Fluvisco (Searle); Hemoantin (Lepetit); Iangene (Farmochim. Ital.); Loctidon (Lepetit); Locton (Lepetit); Octamet (Belphar); Polivasal (Coli); Sudil (Caber); Sulocton (Continental Pharma); Sulodene (Alfa).
C20H35NOS; mol wt 337.56.
C 71.16%, H 10.45%, N 4.15%, O 4.74%, S 9.50%.

Description and references

Prepn: G. Lambelin et al., DE 2334404 (1974 to Continental Pharma), C.A. 82, 97820w (1975). Pharmacology: R. Roncucci et al., Naturwissenschaften 62, 141 (1975); J. Roba et al., Eur. J. Pharmacol. 37, 265 (1976); eidem, Arch. Int. Pharmacodyn. 221, 54 (1976); T. Godfraind, ibid. 342.

Chemical structure

Properties

Crystals from n-pentane or methanol-water, mp 62-63°. LD50 orally in mice: 3700 mg/kg (Lambelin).

Therapeutic Category

Vasodilator (peripheral).

Keywords

Vasodilator (Peripheral)

Status

This monograph has been retired and is no longer subject to revision or update.