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Fig. 11
Dissolution (a) and bioavailability (b) behavior of
sulfathiazole compressed disks with dye; drug alone
(filled circle), drug with FD&C Blue No. 1 (open
circle) [J. Pharm. Sci. 61: 1857, 1970]. |
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Virtually, the success of any drug delivery system, i.e., dosage form, is governed by the drug absorption performance, which is a function of drug release, assuming relatively rapid absorption following its dissolution. Hence, the above three considerations can be viewed in terms of the drug release/dissolution characteristics of the drug delivery system. |
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a. Makoid-Banakar Function (Makoid, Dufore, and Banakar, 1993) The process of the release of a drug from a solid dosage form can be graphed as a |
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