| Table 7 In Vitro and In Vivo Parameters Commonly Used in Establishing Correlation |
| In Vivo Parametera | | | |
AUC(0 ) | %D15, D30 | Tablets | Promethazine |
| kd | Granules | Omeprazole |
| T50% | Microcapsules |  |
|
|
|
|
Bacampicillin hydrochloride |
|
|
|
|
| AUC(0) | %D30 | Tablets | Hydrocortisone |
| AUC(024h) | %D30min | Capsules | Indomethacin |
| AUC(06h) | %D30, %D60 | |
|
|
|
|
Uncoated tablets, capsules (SR), tablets (SR) |
|
|
|
| Theophylline |
| AUC(06h) | %D60, 1/T50% | Tablets | Digoxin |
| AUC | logkd | |
|
|
|
|
Film-coated tablets and controlled-release tablets (insoluble matrix type) |
|
|
|
| Alproclate |
| %D4h | |
|
|
|
|
Tablet (controlled release) |
|
|
|
| |
|
|
|
|
Quinidine gluconate |
|
|
|
|
|
|
|
|
|
F% (rel. to soln.) |
|
|
|
| %D30 | Tablets | Furosemide |
| F% | T50% | Tablets | Nalidixic acid |
| F% | 1/T50% | Tablets | Digoxin |
| F% (6 h) | ks | |
|
|
|
|
Uncoated tablets, capsules (SR), tablets (SR) |
|
|
|
| Theophylline |
| F% (1 h) | %D60 mins | |
|
|
|
|
Uncoated tablets, capsules (SR), tablets (SR) |
|
|
|
| Theophylline |
| Ae (08 h) | T50% | Microcapsules | |
|
|
|
|
Bacampicillin hydrochloride |
|
|
|
|
|
|
|
|
|
Ae (024 h) (steady state) |
|
|
|
| %D6h | Slow-release tablets | Terbutaline |
| Ae (048 h) | %D4h | |
|
|
|
|
Tablets (rapid and slow release) |
|
|
|
| Metformin |
| Ae (048 h) | %D60 | Tablets and capsules | |
|
|
|
|
Triamterene- hydrochlorothiazide |
|
|
|
|
|
|
|
|
|
Ae (072 h) (single dose) |
|
|
|
| %D4h | Slow release | Terbutaline |
| Ae (072 h) | %D60 | Tablets | Chlorothiazide |
| Cmax | %D30 | Suspensions | Trisulfapyrimidine |
| Cmax | D60 | | Nitrofurantoin |