Isometheptene Mucate/Dichloralphenazone/Acetaminophen

A to Z Drug Facts

Isometheptene Mucate/Dichloralphenazone/Acetaminophen

  Action
  Indications
  Contraindications
  Route/Dosage
  Interactions
  Lab Test Interferences
  Adverse Reactions
  Precautions
Patient Care Considerations
  Administration/Storage
  Assessment/Interventions
  Patient/Family Education


(eye-so-meth-EPP-teen MYOO-kate/die-klor-uhl-FEN-uh-zone/ASS-et-ah-MEE-noe-fen)
Isocom, Isopap, Midchlor, Midrin, Migratine
Class: Migraine

 Action Isometheptene mucate acts as sympathomimetic to constrict dilated cranial and cerebral arterioles. Dichloralphenazone is mild sedative that reduces emotional reaction to pain of vascular and tension headaches. Acetaminophen is mild analgesic.

 Indications Relief of tension and vascular headaches. FDA has classified drug as possibly effective in treatment of migraine headaches.

 Contraindications Glaucoma; severe cases of renal disease; hypertension; organic heart disease; hepatic disease; MAO inhibitor therapy.

 Route/Dosage

Migraine Headache

ADULTS: PO 2 capsules at once, followed by 1 capsule q hr until headache is relieved (max 5 capsules in 12 hr period).

Tension Headache

ADULTS: PO 1 to 2 capsules q 4 hr (max 8 capsules/day).

 Interactions

MAO inhibitors: May result in severe headache, hypertension, hyperpyrexia, and possible hypertensive crisis.

 Lab Test Interferences None well documented.

 Adverse Reactions

CNS: Transient dizziness or drowsiness. DERM: Rash.

 Precautions

Pregnancy: Pregnancy category undetermined. Lactation: Undetermined. Children: Safety and efficacy not established. Special risk patients: Observe caution in patients with hypertension or peripheral vascular disease and after recent CV attacks. Hepatotoxicity: Can occur with chronic ingestion of acetaminophen. Chronic alcohol abusers are especially at risk.


PATIENT CARE CONSIDERATIONS


 Administration/Storage

 Assessment/Interventions

OVERDOSAGE: SIGNS & SYMPTOMS
  Nausea; vomiting; drowsiness; confusion; liver tenderness; low or high BP; cardiac arrhythmias; jaundice; acute hepatic and renal failure

 Patient/Family Education

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© 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts