Isoxsuprine HCl

A to Z Drug Facts

 Action Stimulates skeletal beta receptors to produce vasodilation; stimulates cardiac function (increased contractility, heart rate, and cardiac output) and relaxes uterus. At higher doses, inhibits platelet aggregation and decreases blood viscosity.

 Indications Possibly effective for treatment of cerebral vascular insufficiency, peripheral vascular disease caused by arteriosclerosis obliterans, thromboangitis obliterans, Raynaud's disease. Unlabeled use(s): Treatment of dysmenorrhea, premature labor.

 Contraindications Arterial bleeding; use during immediate postpartum period.

 Route/Dosage

ADULTS: PO 10 to 20 mg tid or qid.

 Interactions None well documented.

 Lab Test Interferences None well documented.

 Adverse Reactions

CV: Hypotension; tachycardia; chest pain. CNS: Dizziness; weakness. DERM: Severe rash. GI: Nausea; vomiting; abdominal distress.

 Precautions

Pregnancy: Category C. Lactation: Undetermined.

 Administration/Storage

• Store at room temperature in tightly closed container.

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies. Note cardiovascular disease.
• Monitor for hypotension, tachycardia, and chest pain.
• If rash appears, withhold drug and notify physician.

 Patient/Family Education

• Instruct patient to report the following symptoms to physician: Fast heartbeat, chest pain, pounding in chest, severe rash, flushing, weakness, nausea, vomiting, stomach pain.
• Caution patient to avoid sudden position changes to prevent orthostatic hypotension.

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Copyright © 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts