Lactulose

A to Z Drug Facts

Lactulose

  Action
  Indications
  Contraindications
  Route/Dosage
  Interactions
  Lab Test Interferences
  Adverse Reactions
  Precautions
Patient Care Considerations
  Administration/Storage
  Assessment/Interventions
  Patient/Family Education


(LAK-tyoo-lohs)
Cephulac, Cholac, Chronulac, Constilac, Constulose, Duphalac, Enulose,  Acilac, Gen-Lac, Lactulax, Laxilose, PMS-Lactulose
Class: Laxative

 Action Produces increased osmotic pressure within colon and acidifies its contents, resulting in increased stool water content and stool softening. Causes migration of ammonia from blood into colon where it is converted to ammonium ion and expelled through laxative action.

 Indications Treatment of constipation; prevention and treatment of portal-systemic encephalopathy including stages of hepatic precoma and coma.

 Contraindications Use in patients who require low-galactose diet.

 Route/Dosage

Constipation (Chronulac, Constilac, Duphalac)

ADULTS: PO 15 to 30 mL (10 to 20 g lactulose) daily; may increase to 60 mL/day.

Portal-Systemic Encephalopathy (Cephulac, Cholac, Enulose)

ADULTS: PO 30 to 45 mL tid to qid. Adjust dosage to produce 2 to 3 soft stools/day. Hourly doses of 30 to 45 mL may be used for rapid laxation initially; once achieved, reduce to recommended daily dose. PR 300 mL with 700 mL water or physiologic saline solution via rectal balloon catheter; retain for 30 to 60 min. May repeat q 4 to 6 hr. OLDER CHILDREN AND ADOLESCENTS: PO 40 to 90 mL/day in divided doses to produce 2 to 3 soft stools/day. INFANTS: PO 2.5 to 10 mL/day in divided doses to produce 2 to 3 soft stools/day.

 Interactions

Neomycin, other anti-infectives: May interfere with desired degradation of lactulose and prevent acidification of colonic contents. Nonabsorbable antacids: May inhibit colonic acidification.

 Lab Test Interferences None well documented.

 Adverse Reactions

GI: Gaseous distention with flatulence or belching, abdominal discomfort and cramping; diarrhea; nausea; vomiting.

 Precautions

Pregnancy: Category B. Lactation: Undetermined. Children: Safety and efficacy not established. Administer with caution. Infants receiving lactulose may develop hyponatremia and dehydration. Elderly or debilitated patients: With long-term therapy (> 6 mo) at increased risk of dehydration and electrolyte imbalance. Concomitant laxative use: Do not use other laxatives, especially during initial phase of therapy. Resultant loose stools may falsely suggest adequate lactulose dosage. Diabetic patients: Lactulose syrup contains galactose and lactose. Use drug with caution. Electrocautery procedures: Although not reported for lactulose, theoretical hazard exists for patients being treated with lactulose who may undergo electrocautery procedures during proctoscopy or colonoscopy. Accumulation of hydrogen gas in presence of electrical spark may result in explosion. Therefore patients should have thorough bowel cleansing with nonfermentable solution before undergoing such procedures.


PATIENT CARE CONSIDERATIONS


 Administration/Storage

 Assessment/Interventions

OVERDOSAGE: SIGNS & SYMPTOMS
  Diarrhea, abdominal cramps

 Patient/Family Education

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© 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts