Lomefloxacin HCl

A to Z Drug Facts

Lomefloxacin HCl

	Action
	Indications
	Contraindications
	Route/Dosage
	Interactions
	Lab Test Interferences
	Adverse Reactions
	Precautions
Patient Care Considerations
	Administration/Storage
	Assessment/Interventions
	Patient/Family Education

(low-MUH-FLOX-uh-sin HIGH-droe-KLOR-ide)

Maxaquin

Class: Antibiotic/fluoroquinolone

Action Interferes with microbial DNA synthesis.

Indications Treatment of infections of the lower respiratory tract and urinary tract caused by susceptible organisms; prevention of urinary tract infections in patients undergoing transurethral or transrectal procedures.

Contraindications Hypersensitivity to fluoroquinolones or quinolone antibiotics; tendonitis or tendon rupture associated with quinolone use.

Route/Dosage

ADULTS: PO 400 mg qid for 3 to 14 days.

Surgical Prophylaxis

PO 400 mg 2 to 6 hr preoperatively.

Interactions

Antacids, iron salts, zinc salts, sucralfate, didanosine: Decreased oral absorption of lomefloxacin. Stagger administration times. Antineoplastic agents: Decreased lomefloxacin serum levels. Probenecid: Decreased renal elimination of lomefloxacin.

Lab Test Interferences None well documented.

Adverse Reactions

CNS: Headache; dizziness. DERM: Photosensitivity. GI: Diarrhea; nausea.

Precautions

Pregnancy: Category C. Lactation: Excreted in breast milk. Children: Do not use in children < 18 yr. Elderly: Clearance may be decreased. Chronic bronchitis: Lomefloxacin is not indicated for empiric treatment of acute bacterial exacerbation of chronic bronchitis when Streptococcus pneumoniae is probable pathogen. Convulsions: CNS stimulation can occur; use with caution in patients with known or suspected CNS disorders. Hypersensitivity reactions: Serious and potentially fatal reactions have occurred. Discontinue if allergic reaction occurs. Pseudomembranous colitis: Consider in patients who develop diarrhea. Renal impairment: Reduced clearance may occur; adjust dose accordingly. Superinfection: Use may result in bacterial or fungal overgrowth.

PATIENT CARE CONSIDERATIONS

Administration/Storage

May be administered with or without food; however, absorption is more rapid on empty stomach.
Do not give antacids, sucralfate, iron or zinc-containing products within 2 hr before or after medication.
Store at room temperature in tightly closed, light-resistant container.

Assessment/Interventions

Obtain patient history, including drug history and any known allergies, especially to fluoroquinolones or quinolone antibiotics. Note renal impairment.
Assess patient for signs of infection before beginning treatment.
Obtain specimens for culture and sensitivity before beginning treatment.
Take baseline vital signs and reassess at least bid.
Monitor I&O.
Assess for symptoms of superinfection, such as vaginitis or stomatitis.

OVERDOSAGE: SIGNS & SYMPTOMS
	Renal failure (severely decreased urine output, weight gain, confusion, dry flaky skin), tremor, seizures

Patient/Family Education

Instruct patient to continue taking medication until completed, even if signs and symptoms of infection abate.
Warn patient not to take antacids or vitamins < 4 hr before or 2 hr after taking medication.
Encourage patient to drink plenty of fluids, especially citrus fruit juices and cranberry juice.
Advise patient that drug may cause dizziness and to use caution while driving or performing other tasks requiring mental alertness.
Caution patient to avoid prolonged exposure to sunlight even when using sunscreens or sunblocks, and to wear protective clothing to avoid photosensitivity reaction.
Instruct patient to stop treatment and inform physician if experiencing pain, inflammation, or rupture of tendon, and to rest or refrain from exercise until diagnosis of tendonitis or tendon rupture is excluded.