466. 2-Amino-4-picoline

Nomenclature

CAS number: 695-34-1
4-Methyl-2-pyridinamine; 2-amino-4-methylpyridine; α-amino-γ-picoline; 4-methyl-2-aminopyridine; W-45; Askensil (Atmos).
C6H8N2; mol wt 108.14.
C 66.64%, H 7.46%, N 25.90%.

Description and references

Prepd by heating 4-picoline with sodamide in xylene: Seide, Ber. 57, 791 (1924); 58, 1733 (1925); Rth, ibid. 347. Formulations: von Haxthausen et al., US 2937118 (1960 to Raschig). Pharmacology: von Haxthausen, Arch. Exp. Pathol. Pharmakol. 226, 163; 227, 234 (1955); Marchetti et al., Arch. Int. Pharmacodyn. Ther. 143, 385 (1963).

Chemical structure

Properties

Leaflets from petr ether, mp 100-100.5°. bp11 115-117°. Sublimes on slow heating. Freely sol in water, lower alcohols, dimethylformamide, coal tar bases. Slightly sol in petr ether, aliphatic hydrocarbons.

Therapeutic Category

Cardiotonic.

Keywords

Cardiotonic