467. Aminopromazine

Nomenclature

CAS number: 58-37-7
N1,N1,N2,N2-Tetramethyl-3-(10H-phenothiazin-10-yl)-1,2-propanediamine; 10-[2,3-bis(dimethylamino)propyl]phenothiazine; proquamezine; tetrameprozine; RP-3828.
C19H25N3S; mol wt 327.49.
C 69.68%, H 7.69%, N 12.83%, S 9.79%.

Description and references

Prepn: Jacob et al., Compt. Rend. 243, 1637 (1956); Horclois, GB 800635 (1958 to Rhne-Poulenc).

Chemical structure

Derivative

Fumarate.

Nomenclature

CAS number: 3688-62-8
Lispamol (Specia); Sedofarmolo (Centralvet).
(C19H25N3S)2.C4H4O4; mol wt 771.05.
C 65.42%, H 7.06%, N 10.90%, S 8.32%, O 8.30%.

Properties

Crystals, sensitive to light, dec 166-170°. Soly at 20° (g/100 ml): water 9.0; methanol 5.0; ethanol 0.5. Very slightly sol in isopropanol, acetone. Practically insol in benzene, ether. pH of a 2% aq soln 5.0 to 7.0.

Therapeutic Category

Antispasmodic.

Therapeutic Category (Veterinary)

Antispasmodic.

Keywords

Antispasmodic