813. Arteether

Nomenclature

CAS number: 75887-54-6
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-Ethoxydecahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin; dihydroartemisinin ethyl ether; dihydroqinghaosu ethyl ether; artemotil; SM-227.
C17H28O5; mol wt 312.40.
C 65.36%, H 9.03%, O 25.61%.

Description and references

Derivative of artemisinin, q.v. Prepn: Y. Li et al., Yaoxue Xuebao 16, 429 (1981). Synthesis and antimalarial activity: China Cooperative Research Group on Qinghaosu, J. Tradit. Chin. Med. 2, 9 (1982); A. Brossi et al., J. Med. Chem. 31, 645 (1988).

Chemical structure

Properties

White crystalline solid, mp 80-82°. [α]D21 +154.5° (c = 1.0 in CHCl3).

Therapeutic Category

Antimalarial.

Keywords

Antimalarial