1008. Batimastat

Nomenclature

CAS number: 130370-60-4
(2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide; (2S,3R)-5-methyl-3-[[(αS)-α-(methylcarbamoyl)phenethyl]carbamoyl]-2-[(2-thienylthio)methyl]hexanohydroxamic acid; [4-(N-hydroxyamino)-2R-isobutyl-3S-(2-thienylthiomethyl)succinyl]-l-phenylalanine-N-methylamide; BB-94.
C23H31N3O4S2; mol wt 477.64.
C 57.84%, H 6.54%, N 8.80%, O 13.40%, S 13.43%.

Description and references

Synthetic matrix metalloproteinase inhibitor. Prepn: C. Campion et al., WO 9005719; eidem, US 5240958 (1990, 1993 both to British Biotech.). Effect on transplanted human ovarian carcinoma: B. Davies et al., Cancer Res. 53, 2087 (1993). Inhibition of metastasis of transplanted human colorectal carcinoma: X. Wang et al., ibid. 54, 4726 (1994).

Chemical structure

Properties

Fine white powder. mp 236-238°.

Therapeutic Category

Antineoplastic adjunct (antimetastatic agent).

Keywords

Antineoplastic Adjunct; Antimetastatic Agent; Matrix Metalloproteinase Inhibitor