1049. Benproperine

Nomenclature

CAS number: 2156-27-6
1-[1-Methyl-2-[2-(phenylmethyl)phenoxy]ethyl]piperidine; 1-[1-methyl-2-[(α-phenyl-o-tolyl)oxy]ethyl]piperidine; 1-[2-(2-benzylphenoxy)-1-methylethyl]piperidine.
C21H27NO; mol wt 309.45.
C 81.51%, H 8.79%, N 4.53%, O 5.17%.

Description and references

Prepn: GB 914008; Rubinstein, US 3117059 (1962, 1964 to Aktieselskabet Pharmacia). Pharmacology: Yamatsu et al., Jpn. J. Pharmacol. 17, 538 (1967); N. Tellini, V. De Fina, Boll. Chim. Farm. 109, 476 (1970).

Chemical structure

Properties

Liquid. bp0.2 159-161°. LD50 orally in mice: 1087 mg/kg (Tellini, De Fina).

Derivative

Trihydrogen phosphate.

Nomenclature

CAS number: 19428-14-9
Tussafug (Robugen).
C21H27NO.H3PO4; mol wt 407.44.
C 61.90%, H 7.42%, N 3.44%, O 19.63%, P 7.60%.

Properties

Crystals from abs ethanol, mp 150-152°. LD50 orally in mice: 1431 mg/kg (Tellini, De Fina).

Derivative

Pamoate.

Nomenclature

CAS number: 64238-92-2
Benzproperine embonate; Blascorid (Guidotti); Pirexyl (Pfizer).
(C21H27NO)2.C23H16O6; mol wt 1007.26.
C 77.51%, H 7.00%, N 2.78%, O 12.71%.

Therapeutic Category

Antitussive.

Keywords

Antitussive