1225. Binodenoson

Nomenclature

CAS number: 144348-08-3
2-[(Cyclohexylmethylene)hydrazino]adenosine; MRE-0470; WRC-0470.
C17H25N7O4; mol wt 391.42.
C 52.16%, H 6.44%, N 25.05%, O 16.35%.

Description and references

A2A-adenosine receptor agonist, more selective than adenosine, q.v. Prepn: R. A. Olsson, R. D. Thompson, EP 567094; eidem, US 5278150 (1993, 1994 both to Whitby Research); K. Niiya et al., J. Med. Chem. 35, 4557 (1992). Dose ranging and clinical evaluation as coronary vasodilator in myocardial imaging: J. E. Udelson et al., Circulation 109, 457 (2004). Clinical pharmacokinetics: R. J. Barrett et al., J. Nucl. Cardiol. 12, 166 (2005). Review: A. Zaza, Curr. Opin. Cardiovasc. Pulm. Renal Invest. Drugs 1, 301-306 (1999).

Chemical structure

Properties

Crystals from methanol/water, mp 154-157°.

Therapeutic Category

Diagnostic aid (cardiac stress testing).

Keywords

Diagnostic Aid; Vasodilator (Coronary); Adenosine Receptor Agonist