1224. Binifibrate

Nomenclature

CAS number: 69047-39-8
3-Pyridinecarboxylic acid 2-[2-(4-chlorophenoxy)-2-methyl-1-oxopropoxy]-1,3-propanediyl ester; trihydroxypropane 2-p-chlorophenoxyisobutyrate-1,3-dinicotinate; 2-(p-chlorophenoxy)-2-methylpropionic acid ester with 1,3-dinicotinoyloxy-2-propanol; glyceryl 2-p-chlorophenoxyisobutyrate-1,3-dinicotinate; WAC-104; Biniwas (Wassermann).
C25H23ClN2O7; mol wt 498.91.
C 60.18%, H 4.65%, Cl 7.11%, N 5.61%, O 22.45%.

Description and references

Antilipemic agent structurally related to clofibrate, q.v. Prepn: R. Andreoli, X. Cicera, ES 463218 (1978 to Soc. Espan. Espec. Farm.-Ter.), C.A. 90, 72067h (1979); and pharmacology: eidem, BE 884722 (1980 to Soc. Espan. Espec. Farm.-Ter.). Microhemorheological properties in animals: L. Bruseghini et al., Arzneim.-Forsch. 33, 854 (1983); in patients: M. Dalmau et al., ibid. 858. Clinical evaluation: M. Labios et al., Clin. Hemorheol. Microcirc. 21, 79 (1999).

Chemical structure

Properties

Yellowish-white crystals from alcohol-isopropyl ether, mp 100°. Saponification number 166. LD50 orally in mice and rats: >4000 mg/kg (Andreoli).

Therapeutic Category

Antilipemic.

Keywords

Antilipemic; Fibrates