1472. Bufeniode

Nomenclature

CAS number: 22103-14-6
4-Hydroxy-3,5-diiodo-α-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]benzenemethanol; 1-(4-hydroxy-3,5-diiodophenyl)-2-(1-methyl-3-phenylpropylamino)propanol; diiodobuphenine; Diastal (Bayropharm); Proclival (Houdé).
C19H23I2NO2; mol wt 551.20.
C 41.40%, H 4.21%, I 46.05%, N 2.54%, O 5.81%.

Description and references

Prepn: J. P. Fourneau, J. M. Delourme, ZA 6800046; eidem, US 3542870 (1968, 1970 both to Lab. Houdé). Metabolism: Veyre et al., C. R. Seances Soc. Biol. Ses Fil. 163, 136 (1969).

Chemical structure

Properties

Crystals, mp (slow heating) 185° (dec), mp (fast heating) 212°. LD50 in mice: >600 mg/kg i.p., >2 g/kg orally (Fourneau, Delourme).

Therapeutic Category

Antihypertensive; vasodilator (peripheral).

Keywords

Antihypertensive; Vasodilator (Peripheral)