1633. Cafaminol

Nomenclature

CAS number: 30924-31-3
3,7-Dihydro-8-[(2-hydroxyethyl)methylamino]-1,3,7-trimethyl-1H-purine-2,6-dione; 8-[(2-hydroxyethyl)methylamino]caffeine; 8-(β-oxyethyl)methylaminocaffeine; methylcoffanolamine; Rhinoptil (Promonta).
C11H17N5O3; mol wt 267.28.
C 49.43%, H 6.41%, N 26.20%, O 17.96%.

Description and references

Alkanolamine deriv of caffeine, q.v. Prepn: J. Klosa, DE 1085530; eidem, US 3094531 (1958, 1963 both to Delmar Chemicals Ltd.). Efficacy studies: E. Szirmai, Praxis 13, 412 (1969); R. Leypoldt, Therapiewoche 26, 3381 (1976). Bioavailability and absorption kinetics in humans: H. Walther, K. Kochler, Pharmazie 34, 375 (1979).

Chemical structure

Properties

Colorless crystals from ethanol, mp 162-164°. Soly in water is about 6%; pH of aq solns is 6.9. LD50 s.c. in male mice: 700 mg/kg (Klosa).

Therapeutic Category

Decongestant (nasal).

Keywords

Decongestant