1773. Captodiamine

Nomenclature

CAS number: 486-17-9
2-[[[4-(Butylthio)phenyl]phenylmethyl]thio]-N,N-dimethylethanamine; 2-[p-(butylthio)-α-phenylbenzylthio]-N,N-dimethylethylamine; p-butylmercaptobenzhydryl β-dimethylaminoethyl sulfide; p-butylthiodiphenylmethyl 2-dimethylaminoethyl sulfide; captodiam; captodramin.
C21H29NS2; mol wt 359.59.
C 70.14%, H 8.13%, N 3.90%, S 17.83%.

Description and references

Prepn: Hübner, Petersen, US 2830088 (1958). Pharmacological studies: R. Kopf, I. Moller-Nielsen, Arzneim.-Forsch. 8, 154 (1958).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 904-04-1
Covatine (Bailly); Covatix (G"odecke); Suvren (Ayerst).
C21H29NS2.HCl; mol wt 396.05.
C 63.69%, H 7.63%, N 3.54%, S 16.19%, Cl 8.95%.

Properties

Crystals, mp 131-132°. LD50 (96 hr) in mice, rats (mg/kg): 180, 343 i.p.; 1630, 3800 orally (Kopf, Moller-Nielsen).

Therapeutic Category

Anxiolytic.

Keywords

Anxiolytic