1848. Carnidazole
Nomenclature
CAS number: 42116-76-7
[2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl]carbamothioic
acid O-methyl ester; O-methyl [2-(2-methyl-5-nitroimidazol-1-yl)ethyl]thiocarbamate; R-25831; Spartrix (Janssen). C8H12N4O3S; mol wt 244.27.
C 39.34%, H 4.95%, N 22.94%, O 19.65%, S 13.13%.
Description and references
Prepn and antiprotozoal activity: J. Heeres et al., DE 2429755; eidem, US 3928374 (both 1975 to Janssen); eidem, Eur. J. Med. Chem. - Chim. Ther. 11, 237 (1976). Crystal structure of monohydrate: N. M. Blaton et al., Acta Crystallogr. B35, 753 (1979). Clinical efficacy in vaginal trichomoniasis: A. Notowicz et al., Br. J. Vener. Dis. 53, 129 (1977); P. Chaudhuri, A. C. Drogendijk, Eur. J. Obstet. Gynecol. Reprod. Biol. 10, 325 (1980).
