Recombinant humanized monoclonal antibody Fab fragment linked to polyethylene glycol, q.v.; directed against tumor necrosis factor α (TNF-α). Prepn: D. S. Athwal et al., WO 0194585; eidem, US 02151682 (2001, 2002 both to Celltech). Clinical evaluation in rheumatoid arthritis: E. H. S. Choy et al., Rheumatology 41, 1133 (2002); in Crohn's disease: S. Schreiber et al., Gastroenterology 129, 807 (2005). Review of development and therapeutic potential: S. Rose-John, H. Schooltink, Curr. Opin. Investig. Drugs 4, 588-592 (2003); of clinical evaluation in rheumatoid arthritis: V. V. Kaushik, R. J. Moots, Expert Opin. Biol. Ther. 5, 601-606 (2005).
Anti-inflammatory.
Anti-inflammatory (Biological Response Modifier)