Nomenclature
CAS number: 72-80-0
5,7-Dichloro-2-methyl-8-quinolinol; 5,7-dichloro-8-quinaldinol; 5,7-dichloro-8-hydroxyquinaldine; 5,7-dichloro-2-methyl-8-hydroxyquinoline; hydroxydichloroquinaldine; chloroquinaldol; Gynotherax (Pfizer); Sterosan (Novartis); Steroxin (Novartis).
C
10H
7Cl
2NO; mol wt 228.07.
C 52.66%, H 3.09%, Cl 31.09%, N 6.14%, O 7.02%.
Description and references
Prepd by chlorination of 8-hydroxyquinaldine
with or without formic acid as solvent: Senn, US 2411670 (1946 to Geigy).
Properties
Yellow needles from alc, mp 114-115° (slight decompn). Medicinal odor.
uv max (ethanol): 316 nm (A1%1cm 170); min
280 nm. Practically insol in water. Soly (25°) in ethanol 1.0 g/100
ml of soln; chloroform 5.0 g; acetone 4.0 g; ether 3.0 g; 0.1N NaOH 1.4 g. Also sol in benzene, glacial acetic acid.Therapeutic Category
Antibacterial.
Therapeutic Category (Veterinary)
Antibacterial; antifungal.
Keywords
Antiseptic/Disinfectant; Quinolines