2251. Chrysanthemic Acid
Nomenclature
Description and references
Occurs as esters in pyrethrum flowers, see Pyrethrin I and Cinerin I, also Allethrin (a synthetic product). Isoln and structure: Staudinger, Ruzicka, Helv. Chim. Acta 7, 177, 201 (1924). Synthesis: Staudinger et al., ibid. 390; Campbell, Harper, J. Chem. Soc. 1945, 283; M. J. Devos, A. Krief, Tetrahedron Lett. 1978, 1845; 1979, 1891; O. A. Nesmeyanova et al., Synthesis 1982, 296. Asymmetric synthesis: T. Aratani et al., ibid. 1977, 2599. Stereoselective synthesis of dl-trans-chrysanthemic acid: Mills et al., Chem. Commun. 1971, 555; eidem, J. Chem. Soc. Perkin Trans. 1 1973, 133; S. C. Welch, T. A. Valdes, J. Org. Chem. 42, 2108 (1977); J. P. Genet et al., Tetrahedron Lett. 21, 3183 (1980); of dl-cis-form: J. Mann, A. Thomas, ibid. 27, 3533 (1986). Synthesis of (-)-cis- and (+)-trans-forms: Gopichand et al., Indian J. Chem. 13, 433 (1975).
