2313. Ciprofibrate

Nomenclature

CAS number: 52214-84-3
2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid; 2-[4-(2,2-dichlorocyclopropyl)phenoxy]isobutyric acid; Win-35833; Ciprol (Sterling); Lipanor (Winthrop); Modalim (Sanofi).
C13H14Cl2O3; mol wt 289.15.
C 54.00%, H 4.88%, Cl 24.52%, O 16.60%.

Description and references

Hypolipemic agent, related structurally to clofibrate, q.v. Prepn: D. K. Phillips, DE 2343606 ; idem, US 3948973 (1974, 1976 both to Sterling). Pharmacokinetics in animals and man: C. Davison et al., Drug Metab. Dispos. 3, 520 (1975). Inhibition of cholesterol biosynthesis in rats: A. Arnold et al., Atherosclerosis 32, 155 (1979). Blood levels, distribution, duration of action: J. Edelson et al., ibid. 33, 351 (1979). Metabolic effects: A. Arnold et al., J. Pharm. Sci. 68, 1557 (1979). Teratology study: H. Tuchman-Duplessis et al., Toxicology 12, 1 (1979).

Chemical structure

Properties

Pale cream solid from hexane, mp 114-116°.

Therapeutic Category

Antilipemic.

Keywords

Antilipemic; Fibrates