2357. Clinofibrate

Nomenclature

CAS number: 30299-08-2
2,2′-[Cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methylbutanoic acid]; 2,2′-(4,4′-cyclohexylidenediphenoxy)-2,2′-dimethyldibutyric acid; S-8527; Lipoclin (Sumitomo).
C28H36O6; mol wt 468.58.
C 71.77%, H 7.74%, O 20.49%.

Description and references

Anti-atherosclerosis agent, related structurally to clofibrate, q.v. Prepn: Y. Nakamura et al., DE 2017331; eidem, US 3716583 (1970, 1973 both to Sumitomo). Hypolipidemic activity: K. Toki et al., Atherosclerosis 18, 101 (1973); K. Suzuki et al., Jpn. J. Pharmacol. 24, 407 (1974), C.A. 82, 25821z (1975). Effect on cholesterol and lipoprotein metabolism in rats: K. Suzuki, Biochem. Pharmacol. 25, 325 (1976). General pharmacology: H. Nakatani et al., Oyo Yakuri 16, 687 (1978), C.A. 90, 145808 (1979).

Chemical structure

Properties

Off-white powder, mp 143-146° (dec). Sol in methanol, ethanol, acetone, chloroform, glacial acetic acid. Slightly sol in CCl4. Practically insol in water.

Therapeutic Category

Antilipemic.

Keywords

Antilipemic; Fibrates