2362. Clobenzorex

Nomenclature

CAS number: 13364-32-4
(+)-N-[(2-Chlorophenyl)methyl]-α-methylbenzeneethanamine; (+)-N-(o-chlorobenzyl)-α-methylphenethylamine; d-N-(1-phenyl-2-propyl)-2-chlorobenzylamine.
C16H18ClN; mol wt 259.77.
C 73.98%, H 6.98%, Cl 13.65%, N 5.39%.

Description and references

Prepn and pharmacology: J. R. Boissier, R. Ratouis, FR 1429306 (1966 to Soc. Ind. Fabric. Antibiot.), C.A. 66, 46195h (1967); J. R. Boissier et al., Ann. Pharm. Fr. 24, 57 (1966). Synthesis of labelled compound: J. Lintermans et al., J. Labelled Compd. 6, 289 (1970). Metabolic studies: M. Thomasset et al., Experientia 26, 692 (1970); B. Glasson et al., Arzneim.-Forsch. 21, 1985 (1971).

Chemical structure

Properties

bp0.1 132-134°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 5843-53-8
Ba-7205; SD-271-12; Dinintel (Diamant); Rexigen (Bago).
C16H18ClN.HCl; mol wt 296.23.
C 64.87%, H 6.46%, Cl 23.94%, N 4.73%.

Properties

Crystals, mp 182-183° (isopropanol). [α]D20 +26.3° (water). Sol in water, ethanol. Slightly sol in methanol, chloroform. LD50 i.p. in mice: 103 mg/kg (Boissier et al.).

Therapeutic Category

Anorexic.

Keywords

Anorexic