2395. Cloperastine

Nomenclature

CAS number: 3703-76-2
1-[2-[(4-Chlorophenyl)phenylmethoxy]ethyl]piperidine; 1-[2-[(p-chloro-α-phenylbenzyl)oxy]ethyl]piperidine; p-chlorobenzhydryl 2-(1-piperidyl)ethyl ether.
C20H24ClNO; mol wt 329.86.
C 72.82%, H 7.33%, Cl 10.75%, N 4.25%, O 4.85%.

Description and references

Prepn: GB 670622 (1952 to Parke, Davis); Fujie, Yakugaku Zasshi 81, 693 (1961), C.A. 55, 25848f (1961). Prepn of salts: GB 1179945 (1970 to Yoshitomi Pharm.), C.A. 72, 132549g (1970). Pharmacology: Takagi et al., Yakugaku Zasshi 85, 550 (1965); 87, 907 (1967), C.A. 63, 8932f (1965); 67, 107101u (1967). Metabolism: Kato, Furuta, Oyo Yakuri 5, 735 (1972).

Chemical structure

Properties

bp0.06 172-174°, bp0.15 178-180°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 14984-68-0
Hustazol (Yoshitomi); Nitossil (Zyma); Novotusil (Inpharzam); Seki (Simes).
C20H24ClNO.HCl; mol wt 366.32.
C 65.57%, H 6.88%, Cl 19.36%, N 3.82%, O 4.37%.

Properties

Crystals, mp 147.9°.

Derivative

Methiodide.
C20H24ClNO.CH3I; mol wt 471.80.
C 53.46%, H 5.77%, Cl 7.51%, N 2.97%, O 3.39%, I 26.90%.

Properties

Crystals, mp 140°.

Therapeutic Category

Antitussive.

Keywords

Antitussive