2398. Cloprednol

Nomenclature

CAS number: 5251-34-3
(11β)-6-Chloro-11,17,21-trihydroxypregna-1,4,6-triene-3,20-dione; 6-chloro-Δ1,4,6-pregnatriene-11β,17α,21-triol-3,20-dione; RS-4691; Cloradryn (Recordati); Novacort (Syntex); Syntestan (Syntex).
C21H25ClO5; mol wt 392.87.
C 64.20%, H 6.41%, Cl 9.02%, O 20.36%.

Description and references

Prepn: H. J. Ringold, G. Rosenkranz, FR 1271981 C.A. 58, 1148a (1963); eidem, US 3232965 (1962, 1966 both to Syntex). Metabolic effects: E. Ortega et al., J. Clin. Pharmacol. 16, 122 (1976). Effects on hypothalamic-pituitary-adrenal axis function: eidem, J. Int. Med. Res. 4, 326 (1976). Bioavailability in humans: E. Mroszczak et al., J. Pharm. Sci. 67, 920 (1978). HPLC determn in plasma: C. Lee et al., ibid. 70, 669 (1981).

Chemical structure

Properties

Crystals from acetone/hexane.

Therapeutic Category

Glucocorticoid.

Keywords

Glucocorticoid