2464. Codeine Phosphate

Nomenclature

CAS number: 52-28-8
Galcodine (Galen).
C18H24NO7P; mol wt 397.36.
C 54.41%, H 6.09%, N 3.52%, O 28.18%, P 7.79%.

Derivative

Hemihydrate.

Properties

(U.S.P.), fine, white, needle-shaped crystals or cryst powder. Odorless; affected by light. Solns acid to litmus. Freely sol in water; very sol in hot water; slightly sol in alcohol; more sol in boiling alcohol.

Derivative

Sesquihydrate.

Properties

Very efflorescent, small crystals or cryst powder. One gram dissolves in 2.3 ml water, 0.5 ml water at 80°, 325 ml alcohol, 125 ml boiling alcohol, 4500 ml chloroform, 1875 ml ether. pH of a 2% aq soln: 4.6. Keep well closed.

Note

This is a controlled substance (opiate): 21 CFR, 1308.12.

Therapeutic Category

Analgesic; antitussive.

Therapeutic Category (Veterinary)

Analgesic; antitussive.

Keywords

Analgesic; Opioids; Phenanthrenes; Antitussive