Description and references

A basic anion exchange resin described as a high molecular wt copolymer of diethylenetriamine and 1-chloro-2,3-epoxypropane (hydrochloride), with approx 1 out of 5 amine nitrogens protonated, for which no structural formula has been assigned and for which no specific mol wt information is available, due to the highly cross-linked and insoluble nature of the material. Prepn: Nelson, Van den Berg, DE 1927336; eidem, US 3692895 (1969, 1971 to Upjohn); Lednicer, Peery, DE 2053585; eidem, US 3803237 (1971, 1974 to Upjohn). Activity studies: Parkinson et al., Atherosclerosis 11, 531 (1970); 17, 167 (1973); Marmo et al., G. Arterioscler. 8, 229 (1970); Goodman et al., J. Clin. Invest. 52, 2646 (1973). Toxicology: Webster, Bollert, Toxicol. Appl. Pharmacol. 28, 57 (1974). Review of pharmacology and therapeutic efficacy: R. C. Heel et al., Drugs 19, 161-180 (1980).

Derivative