2537. Coroxon

Nomenclature

CAS number: 321-54-0
Phosphoric acid 3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl diethyl ester; 3-chloro-7-hydroxy-4-methylcoumarin diethyl phosphate; 3-chloro-4-methylumbelliferone diethyl phosphate; O,O-diethyl O-(3-chloro-4-methyl-7-coumarinyl) phosphate; O,O-diethyl O-7-(3-chloro-4-methylumbelliferone) phosphate; coumaphos oxygen analog.
C14H16ClO6P; mol wt 346.70.
C 48.50%, H 4.65%, Cl 10.23%, O 27.69%, P 8.93%.

Description and references

Metabolite of coumaphos, q.v. Prepn: Fusco et al., US 2951851 (1960 to Montecatini); G. C. Amin, C. M. Christian, Indian Chem. Manuf. 12, 22 (1974). Crystal and molecular structure: M. R. Gifkins, R. A. Jacobson, J. Agric. Food Chem. 24, 232 (1976). Determn in eggs and milk: K. D. White et al., J. Assoc. Off. Anal. Chem. 66, 1358 (1983). Ophthalmic cholinesterase inhibitor: M. Kadin, Am. J. Ophthalmol. 50, 622 (1960).

Chemical structure

Properties

Practically insol in water. Somewhat sol in acetone, chloroform, corn oil.

Therapeutic Category (Veterinary)

Anthelmintic.